SPOREs : Organ-Specific SPORE Programs : Breast

Specialized Program of Research Excellence (SPORE) in Breast Cancer

Researchers, clinicians and public health specialists at UNC and UNC Lineberger are working diligently to find new ways of detecting, treating and preventing breast cancer. Their work begins with the National Cancer Institute-funded Specialized Program of Research Excellence (SPORE) in Breast Cancer, one of eleven in the country.

Originally funded in 1992, the UNC SPORE in Breast Cancer has created an outstanding program in translational research. Its current five projects are conceptually linked by studies of breast cancer molecular phenotypes, particularly those with the worst prognosis: basal-like tumors, luminal B tumors, and tumors that overexpress HER2. These projects are led by basic and clinical science teams and include the following:

1. Carolina Breast Cancer Study: Genetic susceptibility for breast cancer subtypes in African Americans and whites
2. Breast cancer vaccine strategies for HER2 and luminal B tumors
3. Determination of breast cancer subtype sensitivities to standard chemotherapy and combination chemotherapy-biologic regimens
4. Molecular portraits of human breast cancer endothelium
5. HER4 Isoforms: Tumor suppressor action and prognostic significance

For more information about these projects, visit http://spores.nci.nih.gov/current/breast/breast_docs/br-earp.html

Researchers involved in SPORE Breast Cancer projects include the following:

Hear from one of our patients, Harriet Farb

Read the latest research news

• Breast Cancer Patients Want Genomic Test That Predicts Risk of Recurrence – 10/18/07
• Obesity may keep some women from getting screened for breast, cervical cancer – 3/24/08
• Researchers Identify New Cell Targets for Preventing Growth of Breast And Other Tumors – 4/23/08

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